Design of Hydrated Porphyrin-Phospholipid Bilayers with Enhanced Magnetic Resonance Contrast.

نویسندگان

  • Shuai Shao
  • Trang Nhu Do
  • Aida Razi
  • Upendra Chitgupi
  • Jumin Geng
  • Richard J Alsop
  • Boris G Dzikovski
  • Maikel C Rheinstädter
  • Joaquin Ortega
  • Mikko Karttunen
  • Joseph A Spernyak
  • Jonathan F Lovell
چکیده

Computer simulations are used to design more hydrated bilayers, formed from amine-modified porphyrin-phospholipids (PoPs). Experiments confirm that the new constructs give rise to bilayers with greater water content. When chelated with manganese, amine-modified PoPs provide improved contrast for magnetic resonance and are safely used for imaging in vivo.

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عنوان ژورنال:
  • Small

دوره 13 1  شماره 

صفحات  -

تاریخ انتشار 2017